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The applicant did not provide new studies on the safety of HPMC, but made reference to previous assessment of celluloses (as a group) performed by other scientific bodies. Cellulose and cellulose derivatives were evaluated for their safety by JECFA (1990), which allocated a group ADI of ‘not specified’. The last comprehensive evaluation of cellulose and cellulose derivatives, including HPMC, for their use as food additives was done in 2017 by the ANS Panel (EFSA ANS Panel, 2018), which concluded that there was no need to set a numerical ADI. Although the data set available for the different celluloses is not complete and most of the studies were old and do not meet the current requirements of toxicological testing, the ANS Panel considered that the physico-chemical, structural, biological and kinetic similarities between the modified celluloses make it possible to apply a read-across approach among the different celluloses.

Furthermore, some individuals may experience headaches or dizziness as a result of HPMC exposure. These symptoms are usually mild and temporary, but if they persist or become severe, it is important to consult a healthcare professional.

Market Trends and Future Outlook

4. Emulsion Stabilizer In latex paints, HEC is used as an emulsion stabilizer. It helps to maintain the stability of the latex particles, ensuring that the paint remains uniformly dispersed and does not separate during storage or application.

In conclusion, buying HPMC involves more than just selecting a product. It requires careful consideration of your application requirements, supplier reliability, product quality, pricing, quantity, and service terms. By conducting thorough research and due diligence, you can ensure a smooth and successful procurement process, maximizing the benefits of this versatile material in your operations.

In the food industry, HPMC is used as a thickener, stabilizer, and emulsifier in a wide range of products such as sauces, dressings, and baked goods. The solubility of HPMC in water allows it to create stable emulsions and gels, improving the texture and mouthfeel of food products.

There are data for microcrystalline cellulose (E 460), methyl cellulose (E 461), hydroxypropyl cellulose (E 463) and sodium carboxymethyl cellulose (E 466), which were tested in mice, rats, hamsters and/or rabbits with oral dosing or via gavage. As regards microcrystalline cellulose (E 460) studies have been conducted in rats (dietary exposure) with a mixture including guar gum or sodium carboxymethylcellulose (E 466) (15% in either case). The NOAEL for both maternal and developmental toxicity were the highest experimental dosages, i.e. 4,500 mg/kg bw (for mixture with guar gum) and 4,600 mg/kg bw (for mixture with sodium carboxymethyl cellulose). Methyl cellulose (E 461) was examined in mice, rats, hamsters and rabbits. In two different studies, pregnant mice were exposed via gavage (vehicle corn oil) to a dose range of 16-1,600 mg methyl cellulose (E 461)/kg bw per day from day 6 to 15 of gestation, followed by a caesarean section at day 17 of gestation. In the first study, maternal toxicity (increase in mortality and reduced pregnancy rate in the survivors) as well as retarded ossification in fetuses were noticed at the highest tested level, pointing to a NOAEL of 345 mg methyl cellulose (E 461) mg/kg bw per day (the last but one highest dosage) in mice. In the second study, no maternal toxicity and fetal abnormalities were observed in mice exposed up to 700 mg methyl cellulose (E 461) mg/kg bw per day. Rat studies (n = 2) were performed in pregnant dams exposed via gavage (vehicle corn oil) to a dose range of 16-1,320 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 15 of gestation followed by a caesarean section at day 20. In the first study (0, 13, 51, 285 or 1,320 mg methyl cellulose (E 461)/kg bw per day) the highest tested dosage resulted in no maternal toxicity but also in increased incidence of extra centres of ossification in vertebrae of fetuses from high dose dams; in a second rat study, the incidence of such alteration slightly increased in fetuses from the highest dosed group (1,200 mg methyl cellulose (E 461)/kg bw per day). Based on the above results, a NOAEL of 285 mg methyl cellulose (E 461) mg/kg bw per day could be identified in rats. No maternal or fetal toxicity was detected in Golden hamsters exposed via gavage (vehicle corn oil) up to 1,000 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 10 of gestation followed by a caesarean section at day 20. The study on rabbits was discarded due to poor experimental design. The only relevant developmental toxicity study with hydroxypropyl cellulose (E 463) (dissolved in 1% gum arabic solution) was performed in pregnant rats exposed via gavage from day 7 to 17 of gestation to 0, 200, 1,000 or 5,000 mg/kg bw test item and some of them subjected to caesarean sections at day 20. No treatment-related adverse effects were detected in dams or in the examined fetuses. A number of dams were allowed to deliver and no clinical, behavioural or morphological changes were observed in the examined pups. Their reproductive ability was seemingly not affected and no abnormalities were found in the F1-derived fetuses. The in utero exposure to the highest dose (5,000 mg/kg bw per day) may be considered as the NOAEL of methyl cellulose (E 461) for this study. No mortality, and no adverse effects were observed on implantation or on fetal survival in pregnant mice or rats dosed via gavage with up to 1,600 mg sodium carboxymethyl cellulose (E 466)/kg bw per day.

Cosmetics and personal care products are another domain where HEC finds extensive use

Hydroxypropyl Methylcellulose (HPMC) is a cellulose derivative that is commonly used in a variety of industries due to its unique properties and versatility. This article aims to explore the characteristics, applications, and benefits of HPMC.

The concentration of HPMC also influences the gelation temperature. As the concentration of HPMC increases, the number of polymer chains in the solution increases, leading to stronger interactions between the chains and a higher gelation temperature As the concentration of HPMC increases, the number of polymer chains in the solution increases, leading to stronger interactions between the chains and a higher gelation temperature

As the concentration of HPMC increases, the number of polymer chains in the solution increases, leading to stronger interactions between the chains and a higher gelation temperature As the concentration of HPMC increases, the number of polymer chains in the solution increases, leading to stronger interactions between the chains and a higher gelation temperature

hpmc gelation temperature. However, beyond a certain concentration, the gelation temperature may decrease due to the formation of aggregates that hinder the entanglement of polymer chains.

For specific applications, such as art supplies or home improvement, specialty stores might carry HEC. For instance, artists might find it in art supply stores for use in paint and mediums, while DIY enthusiasts could look into hardware stores for its use in home repairs or woodworking.

In the pharmaceutical industry, HPMC Ltd’s products are often used as a binder in tablet formulations
hpmc

hpmc ltd. HPMC can improve the hardness, disintegration, and drug release of tablets, making it a valuable ingredient for pharmaceutical manufacturers. It is also used in ophthalmic preparations, topical creams, and suspensions due to its thickening and stabilizing properties.

Emulsifier in ointments

1. Pharmaceutical industry:

Mortar adhesive additive is a crucial component in construction projects that involves the use of mortar. Mortar is a mixture of cement, sand, and water that is commonly used to bind building blocks together. When an adhesive additive is introduced to the mortar mixture, it enhances its adhesive properties, making it stronger and more durable.

HPMC, also known as hypromellose, is derived from cellulose and is commonly used as a thickener, binder, film-former, and stabilizer in a wide range of applications. In the construction industry, HPMC is primarily used in cement-based products such as mortars, renders, and tile adhesives to improve workability, water retention, and adhesion properties. China's booming construction sector has driven the demand for HPMC in recent years, with many domestic manufacturers expanding their production capacity to meet the growing needs of the market.

Intraocularly, hpmc is used as a volume substitute for the aqueous humor to maintain anterior segment integrity and anatomical spaces during intraocular interventions, to protect intraocular tissues (i.e. the corneal endothelium), to sustain corneal transparency as well as for the lubrication of intraocular lenses (IOL) and surgical instruments.

Furthermore, HPMC's biocompatibility and non-toxicity make it suitable for use in a variety of medical devices and implants. For example, it can be used as a coating for surgical sutures, reducing the risk of infection and inflammation. In the field of ophthalmology, HPMC is used in the production of soft contact lenses, providing comfort and improving the wearability of these devices.

1. Concentration The concentration of HPMC will affect the viscosity and stability of the detergent. Too much HPMC may result in a gel-like consistency, while too little may lead to poor suspension and viscosity.

However, it's worth noting that while HPMC is soluble in water, the rate and extent of solubility can vary based on the specific grade and manufacturer. Some HPMC grades might require longer periods or higher temperatures for complete dissolution.

Further complexity arises from the differentiation of HPMC based on its viscosity grade. The viscosity grade indicates the thickening power of an HPMC solution and is typically measured in centipoise (cP). Low-viscosity grades (10-100 cP) are ideal for wet granulation processes due to their enhanced solubility. Medium-viscosity grades (3000-6500 cP) find use in sustained-release matrices, while high-viscosity grades (over 10,000 cP) are employed for thickening and stabilizing suspensions Medium-viscosity grades (3000-6500 cP) find use in sustained-release matrices, while high-viscosity grades (over 10,000 cP) are employed for thickening and stabilizing suspensions

Medium-viscosity grades (3000-6500 cP) find use in sustained-release matrices, while high-viscosity grades (over 10,000 cP) are employed for thickening and stabilizing suspensions Medium-viscosity grades (3000-6500 cP) find use in sustained-release matrices, while high-viscosity grades (over 10,000 cP) are employed for thickening and stabilizing suspensions

hpmc types.

Moreover, HPMC's excellent film-forming characteristics enable its use in film coating processes. Film coating is crucial for improving the appearance, stability, and patient compliance of solid oral dosage forms. HPMC films provide a smooth and uniform coat, protecting the drug from environmental factors such as moisture and light while masking any unpleasant tastes.

In addition to construction, RE dispersible polymer powders find application in coating and paint formulations, where they provide improved adhesion, film-forming properties, and weather resistance. They are also utilized in the production of nonwoven fabrics, serving as binders to hold the fibers together without the need for additional sewing or weaving.

One particular manufacture (naming no names, but one of the big ones) lists it as E464 without the full name…it’s the same thing.

Secondly, HPMC enhances the adhesion of the coating to various substrates, making it more resistant to wear and tear. This is especially beneficial in high-traffic areas or environments where the coating is subjected to extreme conditions.